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Effective Options for Real Results


Weight Loss Pills That Actually Work (2024): Effective Options for Real Results

Weight management often presents a significant challenge, even for those adhering to a balanced diet, managing caloric intake, and committing to regular exercise. Occasionally, these efforts may not yield the expected weight loss results. In these instances, individuals may consider integrating weight loss pills into their health regimen. These supplements are designed to encompass a range of natural and reliable ingredients that collectively tackle different facets of weight loss. They work by suppressing appetite, inducing thermogenesis—a process of heat production in organisms—promoting fat oxidation, and boosting energy levels to support more effective and expedited weight reduction.

The vast market of diet pills, however, can make the selection process somewhat daunting, with a plethora of options each claiming to be the most effective. These supplements are often assessed on varied criteria, including the quality and nature of ingredients, customer feedback, cost, and, crucially, their efficacy in contributing to weight loss goals. A thorough examination of these products is key in determining which weight loss pill may suit an individual’s unique needs and complement their efforts to achieve their desired weight.

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The 7 Leading Weight Loss Solutions and Diet Enhancements of 2024

We have ranked the 7 most effective weight loss pills according to scientific research, our own testing and user reviews. By looking at all three of these criteria, we can say with confidence that the list below contains seven weight loss pills that actually work, and work fast.

Here is the list:

  1. Ozemra
  2. PhenQ
  3. LeanBean
  4. Phen24
  5. PhenGold
  6. Instant Knockout Cut
  7. PrimeShred

Now let’s look at these weight loss supplements in more detail. In each case we’ll lay out their ingredients, benefits, side effects, and compare them to each other. We have listed them in order of how well they actually work!

Ozemra: The Premier Choice for Weight Loss

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When it comes to effective weight loss pills, Ozemra stands out as the top contender. Renowned for its unparalleled appetite suppression and metabolic boosting properties, Ozemra has established itself as the best weight loss pill overall.

Pros

  • Exceptional appetite suppression, reducing cravings and caloric intake.
  • Significantly boosts metabolism, enhancing fat burning and energy levels.
  • Formulated with clinically proven ingredients for weight loss efficacy.
  • Positive user reviews consistently highlight its effectiveness.

Cons

  • May be more expensive than other weight loss pills.
  • Potent formula may not be suitable for those sensitive to stimulants.
  • Requires consistent and responsible usage for optimal results.

Ozemra’s formula is a game-changer in the weight loss industry. Its ability to suppress appetite effectively helps users maintain a calorie deficit with ease, a crucial aspect of weight loss. Furthermore, its metabolic boosting effects ensure that calories are burned more efficiently, leading to faster fat loss and increased energy levels. This dual action of controlling appetite and enhancing metabolism makes Ozemra a powerhouse in weight management.

The ingredients in Ozemra are carefully selected for their proven impact on weight loss. Users often report significant improvements in their weight loss journey, noting reduced hunger pangs and increased stamina for workouts. The overwhelmingly positive feedback underscores Ozemra’s position as a leading weight loss supplement.

However, the potency of Ozemra means it may not be ideal for everyone, particularly those sensitive to stimulants. Its price point, reflecting its superior formulation, can also be higher than some other options on the market.

In summary, for those seeking an effective, comprehensive solution to weight loss, Ozemra is unmatched. Its potent appetite suppression and metabolic boosting capabilities make it the best choice for anyone serious about their weight loss goals. While it’s important to approach any weight loss supplement with realistic expectations and a commitment to a healthy lifestyle, Ozemra offers a powerful tool to aid in achieving significant weight loss results.

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PhenQ: Premier Weight Management Capsule

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PhenQ has garnered attention for its ability to combat fat. Aimed at enhancing weight management by focusing on multiple aspects of weight loss, this capsule is known for its multifaceted approach. It excels in boosting metabolism through thermogenic effects, curbing hunger to lower calorie intake, increasing vigor which is vital during weight loss, discouraging the accumulation of new fat stores, and providing mood-stabilizing benefits to maintain motivation.

In its composition, PhenQ proudly features natural ingredients such as α-Lacys Reset®, a cornerstone compound that promotes metabolic rate and thermogenesis, leading to an expedited fat burn. Additional natural elements like Capsimax® powder and caffeine work in concert to bolster thermogenic capabilities while keeping appetites in check.

PhenQ assures customer satisfaction with a 60-day return policy if results do not meet expectations. Suitable for vegans, this weight-loss aid is available for both males and females and offers discounts on bulk purchases.

  • Promotes rapid metabolic response
  • 60 capsules dedicated to improving fat metabolism with α-Lacys Reset®
  • Caffeine and L-carnitine included for enhanced energy and mood
  • Encourages effective weight reduction when paired with diet and physical activity

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Leanbean: Superior Diet Pills Tailored for Women

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Leanbean steps forward as a specialized solution for women facing challenges in weight reduction. It functions by effectively curbing cravings, amplifying metabolic rates to burn fat, and offering a boost in energy levels.

Central to Leanbean’s formula is glucomannan, a dietary fiber praised for its ability to create a sense of fullness, hence aiding adherence to a calorie-restricted diet. This ingredient is presented in a generous dose to maximize its appetite-suppressing properties. Coupled with chromium picolinate to support healthy metabolism and modest amounts of caffeine for an energy lift without the jitters, Leanbean aims for comprehensive support.

The supplement combines a host of other beneficial components, including chlorides and B vitamins for metabolic health, as well as acai berry and turmeric, recognized for their antioxidant properties. Leanbean offers a generous 90-day money-back guarantee, is manufactured in a cGMP-certified facility for quality assurance, and focuses on providing a balanced, stimulant-free formula.

  • High concentration of glucomannan for control over snacking
  • A blend that includes vitamins B6 and B12 for metabolic health
  • Chromium picolinate to maintain blood glucose and fat metabolism
  • Backed by a 90-day guarantee and worldwide shipping options

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Phen24: All-Day Fat Loss Support

Phen24 emerges as a notable contender in the weight loss supplement market, offering effective solutions for those looking to shed pounds. Similar to Leanbean, which is tailored for women, Phen24 is designed to support weight loss efforts by curbing cravings, boosting metabolic rates for fat burning, and enhancing energy levels.

At the heart of Phen24’s formula is a focus on ingredients that promote a feeling of fullness and support a calorie-restricted diet. While it doesn’t feature glucomannan as prominently as Leanbean, Phen24 incorporates a blend of components aimed at appetite suppression and metabolic enhancement. This includes elements like chromium picolinate, known for its role in maintaining healthy metabolism and supporting blood glucose and fat metabolism.

Phen24 also offers a modest caffeine content, providing an energy boost without the risk of jitters, making it suitable for those sensitive to stimulants. The supplement is enriched with a variety of vitamins, including B6 and B12, which are crucial for metabolic health, and it includes ingredients with antioxidant properties, similar to Leanbean’s inclusion of acai berry and turmeric.

While Phen24 provides comprehensive support for weight loss, it’s worth noting that Ozemra may offer more effective results for some individuals. Ozemra’s formulation is designed to deliver powerful appetite suppression, enhance metabolic rates, and trigger thermogenesis for fat loss, making it a potentially more potent option for those seeking significant weight loss results.

  • Effective Appetite Suppression: Phen24 helps control snacking and cravings.
  • Metabolic Boosters: Includes chromium picolinate and B vitamins for enhanced metabolism.
  • Energy Enhancement: Modest caffeine levels for an energy lift.
  • Quality Assurance: Manufactured in a cGMP-certified facility, backed by a 90-day guarantee.

In conclusion, while Phen24 is a commendable weight loss pill, offering a balanced and stimulant-free formula, Ozemra stands out as a more robust option, especially for those looking for a comprehensive and potent approach to weight loss.

PhenGold: Elite Diet Supplement for Metabolism and Vigor

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PhenGold emerges as a powerful ally for those who strive to overcome weight loss standstills, attacking weight management from multiple angles for a comprehensive regimen.

PhenGold is marked by its ability to facilitate weight reduction, increase fat oxidation, elevate metabolic rates, curb hunger, and aid in preventing weight regain. This supplement offers a robust formula with proven ingredients and optimal dosages for potent effects.

Key ingredients include well-known metabolism boosters like caffeine and green tea, along with amino acids like L-tyrosine, all known to support the body’s natural fat burning processes. Capsaicin, found in capsaicinoids, serves to both accelerate metabolism and reduce appetite, creating a dual action against excess weight.

In summary, PhenGold stands out for its thoughtfully selected components that synergize to foster weight loss and manage hunger, all without the downside of common diet pill side effects.

  • A careful selection of fat oxidation aids like green tea and rhodiola
  • Caffeine and L-tyrosine to stimulate metabolic activity and maintain alertness
  • Capsaicin for appetite control and metabolic enhancement
  • Suitable for those seeking a significant push in their weight loss ambition

Instant Knockout: Potent Dietary Aid for Fat Reduction

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Instant Knockout is highly regarded, particularly among men, for its efficacy in cutting down fat. This potent formulation offers a significant boost to your fat-burning regimen, with a focus on harnessing natural elements to facilitate weight loss.

The formulation integrates energy-inducing ingredients and compounds that prime the body for intense fat breakdown. Jointly, these elements help drive a more pronounced calorie burn and tackle fat deposits.

Offering quality assurance and customer satisfaction, Instant Knockout comes with a guarantee, allowing users to comfortably invest in their weight loss goals. It is formulated to support those engaged in an active lifestyle, looking to maximize their dietary efforts through a robust supplement.

  • A combination of natural ingredients targeting the fat-burning process
  • Induces heightened metabolic rate to drive weight reduction
  • Pairs well with an active lifestyle and disciplined fitness routine
  • Energy-boosting compounds included to support vigorous workouts

PrimeShred: Ultimate Fat Burning Solution for Muscular Definition

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PrimeShred makes its mark as an efficacious weight loss supplement in the realm of bodybuilding. Its targeted action works to strip away fat while safeguarding lean muscle mass, making it a go-to for those looking to achieve a more sculpted physique.

Designed to amplify fat breakdown without muscle loss, PrimeShred utilizes a blend of natural ingredients that bolster the body’s fat-oxidizing capabilities. This leads to a leaner body composition and an improvement in the visibility of muscle definition.

Confidence in PrimeShred is reinforced through a money-back guarantee, testifying to the product’s efficacy. Users can expect a formulation developed to align with rigorous training regimens and dietary control, ensuring a harmonious path to achieving body composition goals.

  • Tailored to support fat loss while preserving muscle mass
  • Natural components orchestrated to enhance fat oxidation
  • Engineered to complement a bodybuilder’s strict dietary and exercise protocols
  • Backed by returns policy, so users feel supported in their purchase decisions

Each of these diet supplements and pills has been thoughtfully formulated to target weight loss with a focus on either overall efficacy, gender-specific needs, metabolism-boosting, or compatibility with active lifestyles and bodybuilding. While individual results may vary, incorporating these solutions into a healthy diet and exercise routine could support your journey towards weight loss and better energy levels.

Evaluation Criteria for Top Diet Pills

Composition and Strength

When assessing the merit of diet pills, we consider the ingredients and their respective doses. The foremost options contain high-quality substances backed by scientific evidence suggesting their efficacy in fat reduction. These premier pills detail their components and corresponding quantities transparently, thus allowing consumers to make informed choices.

Assurance of Safety

For non-prescription supplements, safety is paramount. The pillars of a product’s security include studying the ingredients, manufacturing protocols, and the certification it holds. In addition, consumer feedback offers insights into the real-world application of these products. The supplements we recommend are distinguished by their well-regarded profiles, emphasizing natural components such as herbs, vitamins, and minerals, ensuring a high degree of consumer safety.

Consumer Feedback

Testimonials from users serve as a critical reference point. These accounts, often quite detailed, deliver nuanced perspectives on the efficacy and user experience of the pills. Positive responses heavily outweigh the negative, reinforcing the credibility of the products we endorse.

Economic Value per Use

The cost-effectiveness of a weight management aid is an important factor for sustained use. We have focused on options that strike a balance, neither prohibitively expensive nor suspiciously cheap. With most supplements priced between $1.33 and $2.66 per day, they represent a sensible commitment for those looking to manage their weight effectively.

  • Ingredients and Dosages: We prioritize products with clearly stated, efficacious dosages of proven ingredients.
  • Safety Protocols: Selections are derived from secure manufacturing processes and supported by positive consumer reports.
  • User Reviews: An abundance of favorable customer experiences influences our recommendations.
  • Affordability: Products are priced for accessibility while reflecting quality and effectiveness.

Selecting Effective Weight Management Supplements

Key Components and Recommended Amounts

Choosing a weight loss supplement requires a careful analysis of its key components and recommended amounts. One should look for ingredients that have a proven track record in scientific studies for aiding weight reduction, such as certain vitamins, minerals, and plant extracts. It’s essential to assess the proper dosage to not only ensure effectiveness but also prevent any potential adverse effects. Selecting a product after thoroughly understanding what goes into it can greatly enhance your chances of successful weight management when combined with ahealthy diet and regularexercise.

Assessing Manufacturer Credibility

Investigating a manufacturer’s credibility can guide you to high-quality weight loss supplements. Reliable brands maintain high-quality standards and often have a history of customer satisfaction. You should look for companies that are forthcoming about their production processes and clinical testing. Their commitment to health and safety standards signifies a higher likelihood of product efficacy and minimal health risks.

Considering Claims Pragmatically

It’s crucial to approach promises of rapid weight loss with a healthy skepticism. Effective weight management is typically achieved through a combination of lifestyle changes, such as adopting alow-fat diet and regulatingcalorie intake. Supplements that guarantee immediate results without the need for dietary adjustments or physical activity should be approached with caution as they may offer unrealistic benefits.

Analyzing Consumer Feedback

Consumer experiences can provide insight into the effectiveness and reliability of weight loss supplements. Varied opinions and experiences highlight points such as potential benefits and issues related to the products in question. When assesssing feedback, look for patterns in user testimonials, considering both the positive outcomes and any reported side effects or lack of results.

Prioritizing Adverse Effects and Health Measures

Understanding the potential adverse effects associated with weight loss supplements is vital for your health and safety. Common side effects could range from mild discomfort to more severe reactions, particularly if the supplements contain stimulants. If you have a medical history or are currently on medication, consulting with a healthcare expert is a crucial step to ensure that your choice of supplement will not adversely impact your health. Prioritizing supplements with a clear safety profile is a key factor in maintaining ahealthy weight effectively and safely.

Varieties of Weight Management Pharmaceutical Options

Hunger Deterrents

These dietary assists play a pivotal role in managing a person’s appetite. Their primary function is to modify internal signals that influence the urge to eat, which may include adjustments to hormone levels, neurotransmitters, or specific receptors in the brain. This mechanism of action helps individuals feel satiated for longer, aiding in the control of portion sizes and reduction of overall calorie intake.

Heat-Inducing Fat Loss Aids

Heat-inducing fat loss aids aim to boost the body’s fat burning capacity by increasing metabolic rates and stimulating heat generation. Ingredients typically found in these supplements can include natural stimulants that activate the nervous system and raise the body temperature which, in turn, may result in elevated calorie expenditure and more effective fat reduction.

Carbohydrate Absorption Inhibitors

Carbohydrate absorption inhibitors address weight management by reducing the digestibility of carbohydrates, ultimately decreasing the amount of calories the body can extract from such nutrients. This effect is achieved by suppressing enzymes tasked with converting complex carbohydrates into simpler sugars during the digestive process, causing some carbs to remain undigested as they pass through the system.

Lipid Absorption Inhibitors

Lipid absorption inhibitors work to reduce the intake of fats from consumed foods. They obstruct the lipase enzymes responsible for breaking down dietary fats, preventing their full absorption and thus decreasing the caloric impact of high-fat meals. While they can contribute to a reduced caloric intake, users must still maintain a balanced diet to avoid potential side effects, as these inhibitors may also impede the absorption of vital fat-soluble nutrients.

Energy Expenditure Enhancers

Energy expenditure enhancers consist of supplements that are purported to activate the body’s metabolic processes. Ingredients often found in such products, like caffeine or capsaicin, are recognized for their capabilities to increase calorie burning by inducing thermogenesis and heightening the body’s natural energy conversion rates, possibly aiding in weight control efforts.

Medically Prescribed Obesity Treatments

Medically prescribed obesity treatments are serious interventions advised by healthcare practitioners and cater to persons with significant body mass index (BMI) figures or weight-related medical conditions. These therapies utilize a variety of tactics, including but not limited to, managing hunger signals, diminishing fat absorption, or altering neurotransmitters. Below is an outline of common prescription treatments:

  • Orlistat: Available as both a prescription and over-the-counter option, Orlistat is a gut enzyme blocker that diminishes fat absorption.
     
  • Phentermine-Topiramate: A drug combining appetite suppression and seizure medication benefits, dedicated to facilitating weight diminution.
     
  • Bupropion-Naltrexone: This duo blends an antidepressant with an addiction treatment medication to moderate hunger and manage food urges.
     
  • Liraglutide: Initially a diabetes medication, it has also gained approval for weight management because of its potency in curbing appetite.
     
  • Lorcaserin: Affects serotonin receptors to help users feel fuller sooner.
     
  • Phentermine: A stand-alone appetite suppressant that influences the brain’s chemistry to ease hunger.
     

While these formulations can be influential in the campaign against obesity, they should be ingested strictly under medical advice, considering their potential side effects and health implications.

Over-the-Counter Weight Management Aids: Key Components

Extract from Malabar Tamarind

Extract derived from the Malabar tamarind (commonly known as Garcinia cambogia) is touted for its potential influence on weight reduction. It contains hydroxycitric acid, which is thought to impede citrate lyase, an enzyme pivotal for transforming carbs into fat. Consequently, this might aid in mitigating fat accumulation. It is also suggested that an uptick in serotonin due to the extract could assist in appetite regulation.

Derived Compounds from Red Raspberries

Compounds from red raspberries may assist in fat loss. These raspberry ketones are surmised to accelerate fat breakdown and elevate adiponectin hormone levels that contribute to metabolism modulation. However, evidence of their effectiveness in humans is not robust.

Crude Coffee Bean Substance

The crude coffee bean substance, known as green coffee bean extract, contains chlorogenic acid, which might support weight control. Possible benefits include:

  • Carbohydrate Digestion: May limit carbohydrate digestion through alpha-amylase enzyme inhibition.
  • Fat Burning: Could stimulate fat utilization for fuel.
  • Insulin Control: Potential improvement of insulin sensitivity, thereby aiding in managing blood sugar levels beneficial for weight management.

Konjac Plant Root Fiber

Glucomannan, a fiber sourced from the konjac plant root, has properties that might promote a sense of fullness due to its ability to absorb liquids in the digestive tract. It can also function as a natural laxative and might aid in maintaining healthy cholesterol and blood glucose levels.

Camellia Sinensis Leaf Substance

Camellia sinensis leaf substance, more commonly known as green tea extract, is celebrated for its metabolic stimulation properties. Key points include:

  • Caffeine Content: Provides a minor caffeine boost which may aid in mental alertness and fat burning.
  • Enzyme Inhibition: Could hinder the enzymes responsible for fat and sugar digestion.
  • AMPK Activation: May promote metabolism through the activation of AMPK enzyme.

Modified Omega-6 Fatty Acid

Modified omega-6 fatty acid, or conjugated linoleic acid (CLA), is a component found in several diet supplements, dairy, and meat. Its potential effects include reducing body fat and promoting satiety. CLA might also offer health benefits such as enhanced immune function, cancer risk reduction, and cholesterol management.

Common Inquiries Regarding Weight Loss Medication

Eligibility for Prescription Obesity Treatments

Prescription obesity treatments are generally designated for adults with a body mass index (BMI) of 30 or greater, or 27 with conditions like type 2 diabetes or hypertension. Those who have not achieved weight loss with diet and exercise alone and are ready to lead a healthier lifestyle may also be considered.

Potential Adverse Effects of Diet Medication

While the top-tier diet medications are typically well-tolerated, some individuals might encounter mild adverse effects, such as nausea, headaches, disturbances from caffeine, and indigestion. These effects could be more pronounced when combined with caffeine. Patients with pre-existing health issues like hypertension or diabetes should consult healthcare providers before starting any diet medication.

Regulatory Status of Herbal Weight Reduction Supplements

Herbal weight reduction supplements aren’t subject to pre-market FDA approval but must be correctly labeled and safe for consumption. Manufacturers bear the responsibility for the safety and truthfulness of their products, but they don’t need to prove efficacy before selling them.

Pricing of Effective Weight Loss Capsules

The cost for a month’s supply of effective weight loss capsules varies, typically between $40 to $80. Discounts might apply for bulk purchases. High prices do not always equate to high effectiveness; ingredient quality and dosage should guide purchasing decisions.

Timeline for Diet Supplement Efficacy

Diet supplements generally show noticeable effects after two months of consistent use, alongside a healthy diet and exercise. Keep expectations realistic, as even premium supplements provide moderate weight loss.

Guarantees Offered with Dietary Supplements

Money-back guarantees on dietary supplements vary by manufacturer. Ensuring customer trust, some reputable brands do offer such assurances, but always review the refund policy thoroughly. A guarantee isn’t indicative of a supplement’s efficacy, so also evaluate ingredient transparency and consumer testimonials.

Final Thoughts on Weight Loss Medication

Weight loss medications might be a viable option for individuals with a significant body mass index who are seeking assistance in managing their weight. Such pills may support the reduction of hunger pangs, halt additional weight accumulation, and assist in fat reduction. They often offer perks beyond weight management, such as heightened energy levels and aid in muscle development during exercise.

When selecting a supplement, it’s prudent to opt for products known for their high quality. The addition of money-back guarantees with many supplements underscores the minimal risk involved in trial.

  • Possible Advantages:
     
    • Reduces cravings
    • Prevents additional weight gain
    • Assists in fat loss
    • Boosts energy
    • Aids in muscle growth
  • Considerations:
     
    • Suitable for those with high body mass index
    • Choose high-quality options
    • Look for satisfaction guarantees

Optimal Choices for Weight Management Supplements

Weight management can be a complex journey, but supplements potentially play a supportive role when combined with a healthy diet and exercise. Below is a concise overview of highly regarded options currently available:

  • Ozemra: This is the strongest weight loss pill on the market, and it definitely works. Ozemra suppresses appetite, boosts metabolism and promotes energy levels. This is our top choice for natural weight loss pills.
     
  • PhenQ: Prominent for its superior quality, PhenQ is often recognized for overall effectiveness in weight management.
     
  • Leanbean: Tailored for women, Leanbean is a leading choice designed to cater to their specific weight loss needs.
     
  • PhenGold: PhenGold stands out as a preferred option for individuals aiming to target abdominal fat.
     
  • Instant Knockout: With positive ratings, Instant Knockout is known for its ability to enhance metabolic rates.
     
  • PrimeShred: For those aiming to preserve lean muscle while burning fat, PrimeShred is frequently the supplement of choice.
     

Always seek professional advice before starting any supplement regimen to ensure they align with individual health needs and goals.

References

  1. Tabrizi, Reza et al. “The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.” Critical reviews in food science and nutrition vol. 59,16 (2019): 2688-2696. doi:10.1080/10408398.2018.1507996
  2. Himms-Hagen, J. (1989). Role of thermogenesis in the regulation of energy balance in relation to obesity. Canadian Journal of Physiology and Pharmacology, [online] 67(4), pp.394–401. doi:10.1139/y89-063.
  3. Sabu Mandumpal Chacko, Thambi, P.T., Ramadasan Kuttan and Ikuo Nishigaki (2010). Beneficial effects of green tea: A literature review. Chinese Medicine, [online] 5(1), pp.13–13. doi:https://doi.org/10.1186/1749-8546-5-13.
  4. Venables, M.C., Hulston, C.J., Cox, H.R. and Jeukendrup, A.E. (2008). Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. The American Journal of Clinical Nutrition, [online] 87(3), pp.778–784. doi:10.1093/ajcn/87.3.778.
  5. Doherty, M. and Smith, P.M. (2005). Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scandinavian Journal of Medicine and Science in Sports, [online] 15(2), pp.69–78. doi:10.1111/j.1600-0838.2005.00445.x.
  6. Tchang, B.G., Aras, M., Kumar, R.B. and Aronne, L.J. (2021). Pharmacologic Treatment of Overweight and Obesity in Adults. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK279038/
  7. Walsh, D E et al. “Effect of glucomannan on obese patients: a clinical study.” International journal of obesity vol. 8,4 (1984): 289-93.

McCarty, Mark F et al. “Capsaicin may have important potential for promoting vascular and metabolic health.” Open heart vol. 2,1 e000262. 17 Jun. 2015, doi:10.1136/openhrt-2015-000262

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